Around 20 activists with global animal rights network Direct Action Everywhere (DxE) stood in front of the meat aisle holding placards and carrying flowers for the dead animals.
Placards bore statements including 'Humane murder is a lie' and 'It's not food, it's violence'.
"Why is an aisle of dead animal bodies normal, but speaking out about blatant violence towards defenceless beings extreme?" said a statement by DxE.
"Christmas is a time for love, but we choose to celebrate it by taking the life of another, a completely unnecessary act that creates unimaginable suffering.
"This direct action shines a light on the forgotten victims of this festive season, the turkeys. You can't shop in peace when you're buying death."
A spokesperson for Waitrose said: "We pride ourselves on exceptional animal welfare, with our turkeys farmed to high standards at farms we know and trust."