The range, which is available online and in store, offers styles across womenswear, menswear, and kidswear. Prices start at under £20.
The shoes, which include sandals, trainers, boots, and heels, will feature the same vegan logo found on M&S food products.
"After increased customer interest in veganism and a rise in online searches for related products, we decided to investigate the possibility of expanding our vegan-friendly offering into footwear and accessories," Rachel Smith, Senior Footwear Technologist at M&S, said.
"Over the year we have analyzed our products and gone the extra mile to ensure we offer a great selection that complies with all vegan requirements."
The vegan shoe range follows another major launch by Marks & Spencer, which added around 60 plant-based products to its shelves earlier this month, through its own-brand 'Plant Kitchen' label.
Speaking about the range - which includes options like potato salad and coleslaw - Claire Richardson, who developed the range alongside a team of food experts, said: "Some people think meat-free food is boring but that couldn't be further from the truth, it's experimental – and it's delicious.
"We've created a collection that will appeal to everyone – whether you're a longstanding vegan, want to lead a more flexitarian lifestyle or you love meat but think cauliflower popcorn sounds amazing. It's all about delicious tasting food first - and plant-based second."